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Endocrine Abstracts

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ea0086p322 | Endocrine Cancer and Late Effects | SFEBES2022

Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer

Bruce Isla , Pang Lisa , Poole Amy , Fraser Jennifer

Neuroendocrine castrate resistant prostate cancer (NE-CRPC) is a lethal CRPC subtype that arises as prostate cancer cells transdifferentiate to neuroendocrine cells, evading the potent selective pressure of androgen deprivation therapies (ADT). Currently, clinicians lack biomarkers to detect NE-CRPC evolution and specific therapies to target it. With ~50% of prostate cancer (PC) patients receiving ADT and NE-CRPC accounting for ~25% of CRPC deaths, CRPC and NE-CRPC are a signi...
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ea0065ja3 | Society for Endocrinology Journal Award – Endocrine-Related Cancer | SFEBES2019

Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells

Capodanno Ylenia , Buishand Floryne O , Pang Lisa , Kirpenstenijn Jolle , Mol Jan , Argyle David

Endocrine-Related Cancer, 2018, 25(2): 131–144 (DOI: https://doi.org/10.1530/ERC-17-0415)...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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